A375 is a tumorigenic cell line that was taken from skin cells of a 54-year-old woman who was diagnosed with malignant melanoma. A375 cells are hypotriploid and have a chromosomal modal number of 62. They display an epithelial morphology, as well as grow in adherent monolayers when cultured in vitro. The A375 cell line can be used for either in vivo or in vitro transfection, and Altogen Biosystems offers both an A375 xenograft mouse model and an A375 Transfection Reagent. The A375 cell line is useful for studying skin cancer, as well as other skin infections.
A375 cells have been used as test organisms that also produce paracrine factors for prolonged culture of mesenchymal stromal cells (MSCs). Melanoma is the most lethal formal of skin cancer and is responsible for more than 75% of skin cancer-related deaths. The A375 cell line is relevant to melanoma studies, and it was originally obtained from a 54-year-old female. A375 cells are epithelial-like with adherent properties, hypotriploid, and have a modal number of 62 chromosomes. The cells produce large amounts of amelanotic melanomas in xenografts of NIH swiss mice treated with anti-thymocyte serum. A375 cells are suitable for transfection applications, especially those that deal with oncogenetic factors that are tied to melanomas. For the A375 transfection reagent , visit the Altogen Biosystems website.
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