A375 is a tumorigenic cell line that was taken from skin cells of a 54-year-old woman who was diagnosed with malignant melanoma. A375 cells are hypotriploid and have a chromosomal modal number of 62. They display an epithelial morphology, as well as grow in adherent monolayers when cultured in vitro . The A375 cell line can be used for either in vivo or in vitro transfection, and Altogen Biosystems offers both an A375 xenograft mouse model and an A375 Transfection Reagent . The A375 cell line is useful for studying skin cancer, as well as other skin infections.