A375 Transfection Reagent (Melanoma Cells, CRL-1619)

A375 cells have been used as test organisms that also produce paracrine factors for prolonged culture of mesenchymal stromal cells (MSCs). Melanoma is the most lethal formal of skin cancer and is responsible for more than 75% of skin cancer-related deaths. The A375 cell line is relevant to melanoma studies, and it was originally obtained from a 54-year-old female. A375 cells are epithelial-like with adherent properties, hypotriploid, and have a modal number of 62 chromosomes. The cells produce large amounts of amelanotic melanomas in xenografts of NIH swiss mice treated with anti-thymocyte serum. A375 cells are suitable for transfection applications, especially those that deal with oncogenetic factors that are tied to melanomas. For the A375 transfection reagent , visit the Altogen Biosystems website.

Altogen Biosystems is a ­current global provider of transfection reagents and contract research services for researchers in gene-related fields. Some of the services that are offered include assay development, fast generation of stably-transfected cell lines, and other laboratory services including siRNA screening. For an A375 cell xenograft model  and other valuable resources visit the Altogen Biosystems website.